Research Fields

Epigenetics / DNA Damage Repair

Description: It is likely that DNA damage is a central cause of both the aging phenotype and the increased risk of cancer with age, although there may be significant epigenetic control involved.  Basic research has uncovered complex and highly-conserved mechanisms for controlling DNA repair.  However, it is unknown if there are any interventions discovered that [...]

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Evolutionary Nutrigenomics

Description: This field is based on the presence of evidence in model organisms that there is active genetic control of aging, rather than it being merely a process of passive, accumulated damage.  There is indeed much evidence of this based on the presence of many “longevity mutants”, genetic mutations that can significantly enhance lifespan.  However, [...]

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Brain Remyelination Therapies

Description: Brain myelin integrity is strongly correlated with cognitive performance, and declines progressively after age 30.  Loss of myelin leads to axonal loss, and so remyelination has been theorized to potentially reverse both white and gray matter decline with aging.  Industry focus in remyelination therapies is generally directed at multiple sclerosis treatments, although these therapies [...]

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Autophagy Modulation

Description: Autophagy is the process of cellular recycling.  There is evidence its proper function is important for protection against neurodegenerative disease, infectious disease, and other age-related diseases.  In vivo data has shown transgenic autophagy modulation can improve liver function, but clinical translation efforts have been limited.   Key Group(s): Dr. Ana Maria Cuervo (Albert Einstein [...]

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Maintenance of Tissue Regeneration Potential

Description: An effect of aging, across all organ systems, is the loss of tissue regeneration potential and subsequent loss of functional capacity.  Experiments with heterochronic parabiotic mice (young and old mice, whose circulatory stems have been connected) have shown that youthful serum is able to reverse the decline of tissue regeneration potential in older mice.  [...]

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Tissue and Organ Replacement

Description: Tissue engineering has been an interest of biotechnology companies since the mid-1990’s, where cells, scaffolds, and media are combined to produce new tissue or entire organs.  Production of large, vascular organs (such as the heart, lungs, and liver) has now become possible through whole-organ decellularization methods.  However, clinical translation has been focused on skin [...]

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Telomere Extension

Description: The 2009 Nobel Prize in Medicine was granted to researchers “for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase”.  The shortening of telomeres occurs with age, so various groups are working to develop drugs that active telomerase and extend telomeres.  This class of molecules has shown regenerative effects, but [...]

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Granulocyte Transplantation for Cancer

Description: A strain of cancer-resistant mice were found in 1999, which were immune to even extremely high doses of cancer cells.  The mechanism of action was traced to cell-killing activity by granulocytes, which were able to cure cancer when transplanted into normal mice.  A clinical trial is now being conducted to further test this therapy. [...]

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