Recent News

Blaze/Avelas developing tumor paint technology

I like the approach of Blaze Bioscience and also Avelas Biosciences, who are marking tumors with fluorescent proteins/peptides, with the potential to enable surgeons to fully remove all neighboring cancerous tissue and reduce the likelihood of recurrence. Blaze recently raised a new round of financing and their product is entering toxicology studies, with a Phase [...]

Read more

Richest Man in LA Aims to Make Cancer Patients "Disease-free"

The richest man in Los Angeles isn't an actor, writer, or director, it's Dr. Patrick Soon-Shiong, a man who made billions in the pharmaceutical industry. A significant portion of this wealth was generated through the clinical success of a cancer drug, Abraxane, which has received FDA approval for use in late-stage cancer. Although the drug [...]

Read more

The Importance of the Stem Cell Niche

I was taught the central dogma of tissue engineering is "scaffold - cells - media", and this was ~15 years ago, so the concept of harnessing the cellular microenvironment isn't new. But now with a better understanding of the role of the ECM and vasculature, the availability of iPSC's, microfluidic and 3-D printing technologies, and [...]

Read more

White Matter Hyperintensities and Cerebral Amyloidosis

This study gives more credibility to WMHs detected by MRI not only being a significant part of cognitive aging, but also with Alzheimer's disease. Dr. George Bartzokis at UCLA has published extensively on the role of demyelination in cognitive aging and the production of WMH. This news article and publication however mostly associates WMHs with [...]

Read more

NIH contracts Lonza to make clinical-grade reprogrammed stem cells available for testing

The NIH has contracted Lonza, a major biotechnology industry contract research organization, for the development of clinical-grade iPSC's, or induced pluripotent stem cells. This should help expedite the availability of iPSC's, which can be reprogrammed into most cell types, for testing in a wide variety of clinical trials. http://www.outsourcing-pharma.com/Contract-Manufacturing/Lonza-wins-7m-US-NIH-stem-cell-contract?utm_source=copyright&utm_medium=OnSite&utm_campaign=copyright

Read more

Editorial on the Determination of Human Longevity

In the wild, multi-generational sexually-reproducing biology is a "horse race" between reproductive success and species extinction. If you don't match your replacement rate (~2.1 offspring per couple), you and your kind are history. [~99 percent of all species that have ever lived (as observed from the paleontological record) have lost this race to the force [...]

Read more

High EtOH Kills Neurons

EtOH and the death of neurons in the hippocampus. Small amounts of EtOH are good But it's a "J" curve that ascends upward sharply with increased intake. -- Steve Coles http://news.rutgers.edu/medrel/special-content/fall-2012/binge-drinking-could-20121023

Read more

General Medical Checkups Don't Affect Mortality

180,000 adults were followed in both the USA and Europe for five years from 14 randomized trials and it seems that seeing your doc every year doesn't improve mortality statistics or life expectancy. [1] ...this is a paradox! Cancer screening (PAP tests, mammography, colonoscopy, prostate rectal exams) and annual flu shots are reasons to see [...]

Read more

Multivitamins Cut Cancer Risk

At last, will the anti-supplement establishment take notice this positive result? They are not likely to pitch their tents and steal away silently in the night. Will Pfizer's stock price go up? Where is the US Surgeon General? She has kept such a low profile, we don't even remember her name {Regina Benjamin, M.D. [1]}. [...]

Read more

"Recipe for Immortality" in October 2012 Discover

George Church's new book is called Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves (Basic Books; Available October 2, 2012) "The Recipe For Immortality: An Expert in Synthetic Biology Explains How People Could Soon Live for Centuries" by George Church and Ed Regis Discover Magazine, pp. 60-2, 76 (October 2012) is on the news [...]

Read more

Caloric Restriction in Monkeys at NIH

This study has deep implications for those well-intentioned humans who practice CR in the hopes of extending their lives ( http://www.crsociety.org/) and hold annual meetings to compare notes. They may not have a correct model of the relation between CR and mitophagy (mitochondrial autophagy) due to a reduction in BMR (basal metabolic rate) and the [...]

Read more

The Medical Book: From Witch Doctors to Robot Surgeons

I just received my copy of Clifford A. Pickover's new book The Medical Book: From Witch Doctors to Robot Surgeons, 250 Milestones in the History of Medicine (528 pages; Sterling, New York; 2012) [idiosyncratically, "a" in the word "medical" in the title is actually spelled using the Greek letter "alpha"; Clifford does that sort of [...]

Read more

Longevity vs. Size

Longevity is just one temporal phenotype among a complex set of {biomarkers} for individuals of a species over their collective life history (a cohort all born on the same day). Size is only loosely correlated. The reciprocal of longevity is "mortality," and log mortality rates form the basis for population statistics (Gompertz). Just because an [...]

Read more

CoQ10 + Selenium Clinical Trial

CoQ10 + Selenium. It would be nice to do a dose/response curve to see if more CoQ10 is better or at what stage it ultimately becomes toxic. Too much selenium is known to be bad for you. It's one of those "J" curves, like for alcohol. Personalized genomics may be helpful here. Some people have [...]

Read more

Resveratrol and life expectancy

We removed our recommendation for Resveratrol from our GRG/Bridge-Plan Suggested Supplements more than six months ago. I have never taken Resveratrol myself awaiting more proof, which never came. See full Abstract below. Meta Analyses have their own methodological problems.. Nevertheless, my rule is that humans are not simply big mice, although for many practical purposes [...]

Read more

Eliminate Superfluous Salt from Your Diet (DASH) and Watch Your Total Calories Not the Mix

We need to stop using salt shakers on our food. If NaCl improves the taste of otherwise bland food, it's still not worth the life-shortening consequences of subclinical hypertension (an invisible disease until you suffer a fatal stroke). Ignoring the issue of essential vitamins and minerals, it is also important to mention that all of [...]

Read more

Your Genes May Be Making You Fat, Study Suggests

An excess calorie intake of 100 cal/day as a result of having bad SNP's for the FDO and BDNF genes may not seem like much, but over ten years it can pile on the pounds. Our Supercentenarians tend to be on the slim side. -- Steve Coles http://www.myhealthnewsdaily.com/2638-genes-eating-calories-fat.html

Read more

Anti-Aging Cocktail from Canada

Recent research adds more credibility to our suggested vitamin cocktail based on the research of Dr. C. David Rollo of McMaster University in Ontario, CANADA. His 30-ingredient nutrient mixture is nearly identical to ours (~70 percent) and his mice experience a 28 percent increase in lifespan with improvement in mobility and cognitive function [1]. This [...]

Read more

Essay on the Reality of Aging with Four Contrary Letters to The New York Times

Written by a novelist, here is an accurate (but depressing) description at what befalls us if we don't do anything about aging soon. Thank you, Sir, for telling it like it is! Following the essay are four response letters to The New York Times regarding what they describe as the "joy of aging" (sic). They [...]

Read more

Quote for the Day: The Seeds of Illness

"You can get only so far by going to a doctor when you feel sick.  The seeds of illness may be laid years before."  [p. 66, Discover Magazine (April 2012)] Corollary:  Subclinical chronic illnesses begin in every organ-system of your body when you hit ~30 yo, as measured by the onset of senescence which is [...]

Read more

Latest from Twitter